Dr RC Mishra
Organic, Medicinal and Pharmaceutical Chemist
Welcome to the website!
May 7th
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Hello,
Welcome to my website. I am Ram Chandra Mishra, PhD in Organic and Medicinal Chemistry from Central Drug Research Institute, Lucknow, INDIA. Currently, I am at Biology Department of Georgia State University and working on the design and development of natural product based compounds targeting Tubulin Dynamics as anticancer agents. More about me…
नमस्ते!
हमारे जाल स्थल पर आपका स्वागत है। मैं, राम चन्द्र मिश्र, ने केन्द्रीय औषधि अनुसंधान संस्थान लखनऊ से पी एच डी की उपाधि अर्जित की है। वर्तमान में जार्जिया राज्य विश्विद्यालय के जीव विज्ञान विभाग मे प्राकृतिक उत्पादों पर आधारित कैंसर निरोधी औषधियो की अभिकल्पना और विकास मे संलग्न हूँ। मेरे बारे मे और…
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Use Endnote X4 with Office 2010
Jun 16th
Thomson Reuters made the Endnote X4 available to work with Office 2010 along with some more features.
Untill I get a licensed version from the university a 30 day trial version can be evaulated.
J Med Chem Article: Adenine based acyclic-nucleotides as novel P2X3 receptor ligands
Jul 1st
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Adenine based acyclic-nucleotides as novel P2X3 receptor ligands
Volpini Rosaria; Mishra, RC; Kachare DD; Dalben Diego; Catia Lambertucci; Ippolito Antonini; Vittori sauro; Marucci Gabriella and Nistri Andrea
Abstract:
A new series of acyclic nucleotides based on the adenine skeleton and bearing in 9-position a phosphorylated four carbon chain has been synthesized. Various substituents were introduced in 2-position of the adenine core. The new compounds were evaluated on rat P2X3 receptors, using patch clamp recording from HEK transfected cells and the full P2X3 agonist α,β-meATP as reference compound. The results suggest that certain acyclic nucleotides, in particular compounds 28 and 29, are endowed with modest partial agonism on P2X3 receptors. This is an interesting property that can depress the function of P2X3 receptors, whose activation is believed to be involved in a number of chronic pain conditions including neuropathic pain and migraine. In fact, the new acyclic nucleotides are able to persistently block (by desensitization) P2X3 receptor activity after a brief, modest activation, yet leaving the ability of sensory neurons to mediate responses to standard painful stimuli via a lower level of signaling.
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CHEM MED CHEM Article: Adenosine A2A Receptor Antagonists: New 8-Substituted 9-Ethyladenines as Tools for in vivo Rat Models of Parkinson’s Disease
Jun 24th
Adenosine A2A Receptor Antagonists: New 8-Substituted 9-Ethyladenines as Tools for in vivo Rat Models of Parkinson’s Disease
Rosaria Volpini, Prof., Diego Dal Ben, Dr., Catia Lambertucci, Dr., Gabriella Marucci, Prof. Dr., Ram Chandra Mishra, Dr., Anna Teresa Ramadori, Dr., Karl-Norbert Klotz, Prof., Maria Letizia Trincavelli, Dr. , Claudia Martini, Prof., Gloria Cristalli, Prof.
Abstract:
A new series of 8-substituted 9-ethyladenine derivatives has been synthesized and tested at rat and human adenosine receptors. Binding data demonstrates that some compounds could represent new tools suitable for in vivo studies in rat models of Parkinson’s disease and for the design of new molecules with improved affinity and selectivity at human AA2AR.
Clinical evidence has demonstrated that AA2AR antagonists could be an alternative approach to the treatment of Parkinson’s disease. Recently, three 9-ethyladenine derivatives bearing a bromine atom, an ethoxy group, and a furyl ring, respectively, in the 8-position have been reported to ameliorate motor deficits in rat Parkinson’s disease models, suggesting a potential therapeutic role for these compounds. Starting from these observations, a new series of 9-ethyladenine derivatives, bearing different substituents such as halogens, alkoxy groups, aromatic and heteroaromatic rings in the 8-position, were synthesized. Radioligand binding assays demonstrated that some of the new compounds bind rat AA2AR with higher affinity than the previously reported congeners and that there is a good correlation between binding to rat and human receptors. Hence, the new molecules could represent new tools suitable for the in vivo studies in rat models of Parkinson’s disease. Finally, a molecular docking analysis of the compounds was performed using a homology model of rat AA2AR, built using the human crystal structure as the template, and results are in agreement with the binding data.
Abstract | References | Full Text: HTML, PDF (Size: 518K) | Related Articles | Citation Tracking
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Indian Turmeric’s (हल्दी) healing secret, finally revealed?
Apr 23rd
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J. Am. Chem. Soc., 2009, 131 (12), 4490-4498
Copyright 2009 American Chemical Society
Scientists in Michigan are reporting discovery of the secret behind the fabled healing power of the main ingredient in turmeric – a spice revered in India as “holy powder.” Their study on the ingredient, curcumin, appears in the Journal of the American Chemical Society, a weekly publication.
In the study, Ayyalusamy Ramamoorthy and colleagues point out that turmeric has been used for centuries in folk medicine to treat wounds, infections, and other health problems. Although modern scientific research on the spice has burgeoned in recent years, scientists until now did not know exactly how curcumin works inside the body.
http://www.medicalnewstoday.com/articles/146512.php
Medical News Today (U.K.: 1.8 million monthly unique users)
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JACS on Twitter…twittering from Salt Lake City
Mar 23rd
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TWITTER is a social networking tool that allows for real-time “micro-blogging” of short messages.
Now follow JACS’s twitter feed to stay in the loop about exciting JACS content, new features on JACS Beta, breaking news, upcoming events, and more. If you’d like to learn more about how Twitter works, please read the Twitter FAQ.
- Go to JACS’ Twitter Page for more info or connect to JACS on Twitter here
- ACS staff will be tweeting at the ACS National Meeting in Salt Lake City, March 22-26.
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Reaxys, the new workflow solution for chemists
Mar 19th
Reaxys, the new workflow solution for chemists, was released in January.
How can Reaxys help you as a researcher?
This innovative solution delivers exactly what you need.
- Synthesis planner: compares synthesis routes across publications and get a single overview enabling you to reach the appropriate route faster
- Superior reaction content: content from top journals and patent literature, selected by experts
- Filter and rank your search results according to preference – key properties, synthesis yield or other criteria
- Commercially available chemicals are flagged to directories (eMolecules and Symyx ACD): avoid synthesizing unnecessary compounds
- Additional search capabilities – you can generate structure queries from chemical names
Interested in more information or a free trial?
Take a look here for more details
Sincerely,
The Reaxys Team
The anti-cancer activity of Noscapine: A Review
Jan 30th
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Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally.When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anti-cancer agents.
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FDA Clears Stem Cell Clinical Trial
Jan 27th
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FDA‘s decision “marks the dawn of a new era in medical therapeutics,” Thomas B. Okarma, president and CEO of Geron, said during a teleconference briefing. GRNOPC1 is intended to “permanently reverse disease pathology, not merely to temporarily relieve symptoms,” he noted.
via FDA Clears Stem Cell Clinical Trial | Chemical & Engineering News: Latest News.
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Met Prof. Dr. Erik de Clercq
Jan 17th
It was the annual New Year’s Lunch Party for Rega Institute’s Med Chem Team at Groot Begijnhof.
As we were leaving after finishing our lunch, he was curious to see five indians in the team and asked, if I am from Pune (India). I told that I am from Lucknow, if he knows..He said he knows Saxena (Dr Anil Kumar Saxena, AK Saxena) there and has collaboration with around 60 labs in India. As I did my PhD from there (CDRI, Lucknow) and worked in Dr Saxena’s lab (I was working in Tripathi Research Group).
Prof. Erik De Clercq
Bijzonder gasthoogleraar (Emeritus Professor), Department of Microbiology and Immunology
Since I came to Rega, I was very eager to see him
