Anticancer targets amenable by nucleoside drugs

Anticancer chemotherapy using targets amenable by nucleoside drugs: There are some recently discovered targets where compounds of ‘nucleoside’ class or just the ‘Nucleosides’ have shown some interesting biological effects.  Most of these could be modulated to get novel nucleoside based highly targeted therapy of various cancer sub types.

Bosutinib – Bosulif approved for Leukemia by Pfizer

A new anticancer drug for Leukemia has been approved by FDA. The drug treats chronic myelogenous leukemia (CML), a blood and bone marrow disease that usually affects seniors.   It works by inhibiting the enzyme Tyrosine Kinase.  

Centrosome Declustering: An Anticancer Strategy

Centrosome clustering  is a phenomenon associated with tumorigenesis. The clustering of centrosomes in cancer cells enables them to form a pseudo-bipolar mitotic spindle.   In cases which are very rare, this mechanism fails resulting in declustered centrosomes leading to a multipolar spindle. Spindle multipolarity in turn leads to mitotic arrest and finally cell death.

Design & Development of Unnatural Nucleosides as Antiviral & Anti-Cancer Agents

Design & Development of Unnatural Nucleosides as Antiviral & Anti-Cancer Agents   Ram C. Mishra   College of Pharmacy, University of Georgia, GA 30602, USA  Unnatural nucleosides are the variants (chemically modified analogs) of five natural nucleosides which constitute the structure of DNA and RNA. Since the first preparation and later, the isolation of unnatural … Read more

Gemcitabine Phosphoramidate as New Anticancer Clinical Candidate

Prof. McGuigan from Cardiff School of Pharmacy, UK along with Prof. Jan Balzarini of Rega Instutute for Medical Research, Belgium have reported an innovative approach to overcome the cancer Resistance mechanism using the pro-tide technology of their’s. They prepared various Nucleotide Phosphoramidates of the known anticancer drug Gemcitabine and were able to find a molecule … Read more