Dr RC Mishra

Process can fabricate a custom-order, complex carbohydrate molecule in 24 hours. Current commercial technology requires six to 12 months for the same molecule at a cost that can be 10 times higher than Pohl’s technology

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Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally.When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anti-cancer agents.

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Describe here are, two approaches for the synthesis of 2′-C-β-methyl-2′-deoxyguanosine 3 via 2′-radical deoxygenation. One approach starts from 1,3,5-tri-O-benzoyl-α-d-ribofuranose 6 and gives 3 in 11 steps with 9.7% overall yield. The second approach starts from guanosine and gives 3 in 8 steps with 23% overall yield.

2′-C-Branched nucleosides represent a class of nucleoside analogues that have potential utility as therapeutic agents and as probes to study RNA structure and function.1-11 For example, 2′-C-β-methyl and 2′-deoxy-2′-C-α/β-methyl ribonucleosides, including 2′-C-β-methylguanosine 1, have antitumor and antiviral activities as inhibitors for Hepatitis C viral RNA replication.1-9 Recently, we used 2′-C-β-methyl nucleosides and 2′-deoxy-2′-C-α/β-methyl nucleosides, including 2′-C-α-methyl-2′-deoxyguanosine 2, to study the packing density of the P4−P6 RNA domain and the mechanism of Group II intron catalysis.10, 11 We previously reported an efficient synthesis of 2′-C-β-methylguanosine 112 and 2′-C-α-methyl-2′-deoxyguanosine 2.13 Here we report the synthesis of 2′-C-β-methyl-2′-deoxyguanosine 3 Figure 1.

via Synthesis of 2′-C-β-Methyl-2′-deoxyguanosine – The Journal of Organic Chemistry ACS Publications.