Publication

CHEM MED CHEM Article: Adenosine A2A Receptor Antagonists: New 8-Substituted 9-Ethyladenines as Tools for in vivo Rat Models of Parkinson’s Disease

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Adenosine A2A Receptor Antagonists: New 8-Substituted 9-Ethyladenines as Tools for in vivo Rat Models of Parkinson’s Disease Rosaria Volpini, Prof., Diego Dal Ben, Dr., Catia Lambertucci, Dr., Gabriella Marucci, Prof. Dr., Ram Chandra Mishra, Dr., Anna Teresa Ramadori, Dr., Karl-Norbert Klotz, Prof., Maria Letizia Trincavelli, Dr. , Claudia Martini, Prof., Gloria Cristalli, Prof. Abstract: A new series of 8-substituted 9-ethyladenine … Read more

J Med Chem Article: Adenine based acyclic-nucleotides as novel P2X3 receptor ligands

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Image via Wikipedia Adenine based acyclic-nucleotides as novel P2X3 receptor ligands Volpini Rosaria; Mishra, RC; Kachare DD; Dalben Diego; Catia Lambertucci; Ippolito Antonini; Vittori sauro; Marucci Gabriella and Nistri Andrea Abstract: A new series of acyclic nucleotides based on the adenine skeleton and bearing in 9-position a phosphorylated four carbon chain has been synthesized. Various … Read more

Chem Med Chem: Inside Cover: Very Important Paper

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June 2011 issue of the Chem Med Chem’s inside cover represents our VIP Article titled, “Evidence for the Existence of a Specific G Protein-Coupled Receptor Activated by Guanosine“. The article can be downloaded from Here or directly from from Wiley.

New Synthesis of ‘FMCA’: A potential Anti-HBV Drug Candidate

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A new and potent anti-HBV drug candidate has been discovered by our research group here at Drug Discovery Group (College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences) of the University of Georgia.   FMCA stands for Fluoro and Methylene substituted derivative of Carbocyclic Adenosine. It has a 2’-F substitution and 6’ exocyclic methylene group … Read more

Di-substituted Noscapine Analogs as Potent Anticancer Agents

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Noscapine is an opium-derived kinder and gentler microtubule affecting drug, currently in clinical trials for cancer chemotherapy. Here, we report the synthesis of four potent di-substituted derivatives of noscapine and their effect on Prostate Cancer and Breast cancer cells. These have higher tubulin binding than noscapine and affect its polymerization. The equilibrium dissociation constant between tubulin and new compounds is … Read more