Anticancer chemotherapy using targets amenable by nucleoside drugs: There are some recently discovered targets where compounds of ‘nucleoside’ class or just the ‘Nucleosides’ have shown some interesting biological effects. Most of these could be modulated to get novel nucleoside based highly targeted therapy of various cancer sub types.
The compound with the structure below is a Bayer’ patented anticancer drug for renal and liver cancer, marketed as Nexavar.
Design & Development of Unnatural Nucleosides as Antiviral & Anti-Cancer Agents Ram C. Mishra College of Pharmacy, University of Georgia, GA 30602, USA Unnatural nucleosides are the variants (chemically modified analogs) of five natural nucleosides which constitute the structure of DNA and RNA. Since the first preparation and later, the isolation of unnatural … Read more