The anti-cancer activity of Noscapine: A Review

Image via Wikipedia Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally.When the resistance to other anti-cancer drugs … Read more

CHEM MED CHEM Article: Adenosine A2A Receptor Antagonists: New 8-Substituted 9-Ethyladenines as Tools for in vivo Rat Models of Parkinson’s Disease

Adenosine A2A Receptor Antagonists: New 8-Substituted 9-Ethyladenines as Tools for in vivo Rat Models of Parkinson’s Disease Rosaria Volpini, Prof., Diego Dal Ben, Dr., Catia Lambertucci, Dr., Gabriella Marucci, Prof. Dr., Ram Chandra Mishra, Dr., Anna Teresa Ramadori, Dr., Karl-Norbert Klotz, Prof., Maria Letizia Trincavelli, Dr. , Claudia Martini, Prof., Gloria Cristalli, Prof. Abstract: A new series of 8-substituted 9-ethyladenine … Read more

J Med Chem Article: Adenine based acyclic-nucleotides as novel P2X3 receptor ligands

Image via Wikipedia Adenine based acyclic-nucleotides as novel P2X3 receptor ligands Volpini Rosaria; Mishra, RC; Kachare DD; Dalben Diego; Catia Lambertucci; Ippolito Antonini; Vittori sauro; Marucci Gabriella and Nistri Andrea Abstract: A new series of acyclic nucleotides based on the adenine skeleton and bearing in 9-position a phosphorylated four carbon chain has been synthesized. Various … Read more